The goal of protein engineering is to optimize a protein sequence to improve its functionality. ForgeCraft is complementary to rational design and directed evolution work flows typically used in protein engineering delivering a dramatic increase in throughput and scope with which a researcher can identify variants of improved functionality.
The exceptional flexibility afforded by the rational design offered by ForgeCraft supports sophisticated enzyme sequence analysis and advanced engineering of binding domain affinity, specificity, and stability, while allowing the incorporation of structure and/or activity mapping data. The extreme elasticity of the ForgeCraft approach is unrivaled and cannot be achieved by existing engineering methods.
ForgeCraft enables multiple protein engineering strategies, such as: